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It prevents progression of anemia and nerve damage by supplying B directly, even when intrinsic factor (the gastric protein needed for oral B12 absorption) is lacking

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Low levels of vitamin B12 (vitamin B12 deficiency)

Age-related changes post-40 stem from diminished cellular resilience and repair.[3][11] This resilience is tied to the body's ability to handle oxidative stress and maintain homeostasis, processes that falter as NAD+ levels wane