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Tracer studies employing 13C-labeled lactate have demonstrated robust incorporation of lactate-derived carbon into TCA intermediates across a wide array of tissues, encompassing both healthy and malignant cells (31,32)

GOT1 and GOT2 catalyze the transamination reaction between oxaloacetate and glutamate to produce aspartate and -KG

Cell Metab 9(5):461473 Zhang Y, Zhao S, Fu Y, Yan L, Feng Y, Chen Y, Wu Y et al (2020) Computational repositioning of dimethyl fumarate for treating alcoholic liver disease

Glutathione is a key nutrient for gut health, and liposomal glutathione supplementation can help improve gut function and reduce inflammation

(d) none of the patients had a history of addiction or substance abuse in the last year

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