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Orlistat is generally the least favored option due to its side effect profile, and its benefit is reduced if an individual is already following a low-fat diet, although gastrointestinal side effects may persist

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It mimics your bodys natural Growth Hormone Releasing Hormone (GHRH) and binds to GHRH receptors in the hypothalamus

JAMA Psychiatry 70 , 619629 (2013)

It appears to activate the ghrelin receptors (GHSR) which appear to trigger growth hormone synthesis