In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)
However, as vitamin D excess can be problematic, I always recommend testing before supplementing
Drmic et al., Counteraction of perforated cecum lesions in rats: Effects of pentadecapeptide BPC 157, L-NAME and L-arginine, World J
The takeaway is that B12 injections are usually considered very safe, and side effects are uncommon when used appropriately
A typical dosing schedule would look something like this: Starting dose: 0.25 mg semaglutide once per week for four weeks
We set realistic expectations up front, track real markers and measurements over time rather than just the scale, and adjust your plan based on how your body actually responds