Johns Wort (an herbal antidepressant), some opioid painkillers (like tramadol, meperidine), and even the anti-parkinson medication selegiline
It is typically prescribed as part of a comprehensive weight management program that includes diet and exercise
Semaglutide works by increasing insulin secretion, decreasing glucagon secretion, slowing gastric emptying, and promoting a feeling of fullness (satiety)
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Doctors can prescribe pramlintide off label for weight loss, but it is not officially approved for this use