10.1016/j.jpsychires.2014.02.005 7
Future Microbiol
Based on Phase 2 trial data (Jastreboff et al., NEJM , 2023), the most commonly reported adverse effects of retatrutide include: Gastrointestinal effects: Nausea, vomiting, diarrhoea, and constipation (most frequent, particularly during dose escalation) Injection site reactions: Redness, bruising, or mild discomfort Decreased appetite: Generally considered a therapeutic effect but can contribute to nutritional deficiency if severe Increased heart rate: Observed with glucagon receptor agonism
6 Importantly, this method is associated with numerous limitations, including variability between batches, time-consuming requirements, and difficulties in ensuring consistent quality when applied to commercial production settings
(It is now available to rewatch if you sit through an earlier Q&A about an unrelated supplement in the Highlights tab.) The most easy-to-find information about berberine on the companys Instagram account is a Reel promoting the ingredient as a supplement you dont want to miss. In addition to GI support, the promotion hails berberine for its weight-management properties
But even with a perfectly stable capsule, the timing still matters