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The MHRA has received more than 40 reports relating to pregnancy among women on the drugs
Clinical studies show that people taking tirzepatide lose weight primarily through fat loss, but some loss of lean mass, which includes muscle, can occur, especially during rapid weight reduction
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Activated Th1 and Th17 cells produce inflammatory products and cytokines that disrupt myelin and axons and activate retained microglia, which in turn generate inflammatory cells that attract more inflammatory cells to the central nervous system (CNS) and perpetuate the inflammatory cascade (47)
As such, tirzepatide may offer significant potential value for patients, payers, and society, and the findings highlight the importance of considering long-term value rather than upfront drug costs alone