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doi: 10.1016/j.ejps.2018.11.037 58 SawamuraTKarashimaSNagaseSNamboHShimizuEHigashitaniTet al

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Exendin-4 proved also to be a potent agonist of GLP-1 by decreasing both food and water intake in a dose-dependent manner

Ipamorelin is a growth hormone (GH) secretagogue that mimics ghrelin and selectively binds the same GHSR-1a receptor as endogenous ghrelin [10]

They both consisting of: An extracellular N-terminus that binds the C-terminal part of the incretin analog A seven transmembrane helical domain (TMD) with the a-helices separated by three intracellular loops and three extracellular loops An intracellular C-terminus that is responsible for signaling