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Nevertheless, the current evidence remains largely inconclusive and does not demonstrate any clear benefit of a gluten-free diet (GFD) in patients without concomitant celiac disease, warranting further investigation [141,144,145,146,147,148,149]

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Interestingly, despite increased expression of the anti-apoptotic protein BCL2 in failing hearts, programmed cell death still occurs, suggesting a complex regulatory process [116]

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