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Tirzepatide is a dual agonist that co-activates the GIP receptor (glucose-dependent insulinotropic polypeptide receptor) alongside GLP-1R

10.1080/15548627.2023.2213984 Autophagy 50 LiR.LiR.XieJ.ChenJ.LiuS.PanA.et al (2023)

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However, excessive iron accumulation can lead to neuronal death through ferroptosis and exacerbated inflammation (Xiong et al., 2019)

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