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PMID: 32019204

Microbiome and metabolome reveal the metabolic and microbial variations induced by depression and constipation

This interaction underscores a broader metabolic complementarity: while GLP-1 RAs primarily drive weight loss through appetite suppression, delayed gastric emptying, and insulinotropic effects, microbiota-targeted interventions may act on additional pathways involved in energy expenditure, substrate utilization, and muscle preservation, thereby potentially reducing inter-individual variability in therapeutic outcomes

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