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I understand tirzepatide is a dual-action GIP/GLP-1 agonist and may produce stronger weight loss results, while semaglutide has a longer track record
Average weight loss is 15% of body weight over 68 weeks, based on the STEP 1 trial
Semaglutide GLP-1 activates areas in the brain that control appetite, reducing hunger and increasing feelings of satisfaction
SeekPeptides members already access detailed stacking protocols and dosing tools through our peptide stack calculator for combinations like this one
Important: Semaglutide is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), and is not recommended during pregnancy, especially when used for weight management
Pharmaceuticals (2025) 13
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