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The activated forms of mTOR and S6K1 are localized mainly in the paraventricular and arcuate nuclei [119], being co-localized in a high percentage of orexigenic neurons that express AgRP/NPY and also in around half the anorexigenic neurons that express POMC/CART in the arcuate nuclei [119]
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This extreme brevity makes native GHRH largely impractical as a sustained research tool
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