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Phan J, Sio TT, Nguyen TP, Takiar V, Gunn GB, Garden AS, Rosenthal DI, Fuller CD, Morrison WH, Beadle B, Ma D, Zafereo ME , Hutcheson KA, Kupferman ME, William WN, Frank SJ

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Lancet (2016) 388(10060):265464

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72 All other data supporting the findings of this study are available from the corresponding author upon reasonable request

There is no evidence that doses above 500mcg produce proportionally better results, and clinical trials using 1mg daily did not dramatically outperform lower doses