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Compile Your Health History Some people may not be a good fit for certain GLP-1sfor example, those with a personal or family history of Medullary Thyroid Cancer (MTC) or those who take other blood-sugar regulating medicationscombining the two can result in low blood sugar levels

Preclinical studies and early clinical trials suggest that a balanced tri-receptor agonist may achieve metabolic benefits that mimic or surpass those observed following metabolic surgery [65]

Although the ELIXA studythe only CVD outcome trial of GLP-1 RAs published to datereported a neutral cardiovascular effect of lixisenatide, the potential cardiovascular benefits of GLP-1 RAs should not be overlooked, because high-risk subjects with established CVD were recruited in this study to delineate its cardiovascular safety within a short-term period

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