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Key Takeaway The NICE 2026 update highlights a shift from purely glycaemic control to early cardiovascular and renal protection, supporting the earlier use of SGLT2 inhibitors and GLP-1based therapies in appropriate patients
GLP-1 and GIP/GLP-1 medications have boxed warnings regarding thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and carry risks of pancreatitis, gallbladder disease, and diabetic retinopathy progression
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The timeframe to observe the benefits of L-carnitine supplementation can differ from person to person
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