Retrieved from Seifarth, C., Schehler, B., & Schneider, H
Aetna is the brand name used for products and services provided by one or more of the Aetna group of companies, including Aetna Life Insurance Company and its affiliates (Aetna)
Key results: On-treatment (no interruptions): Semaglutide (Wegovy): 57% lower risk of heart attack, stroke, or death Tirzepatide: Reference comparator Including treatment gaps: Semaglutide: 29% lower risk of major adverse cardiovascular events Tirzepatide: Higher event rates in this real-world analysis Why this matters: These data suggest semaglutide may have greater cardiovascular benefit than tirzepatidea provocative finding given both are highly effective for weight loss
[DOI] [Google Scholar] Pastore A., Federici G., Bertini E., Piemonte F
This suggests that Retatrutides activity on GLP-1, GIP, and glucagon pathways interacts with underlying insulin sensitivity
Ozempic and Wegovy use the same active ingredient, semaglutide