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Notably, the tripartite inter-organ crosstalk between the gut, liver and skeletal muscle (i.e., the gut-liver-muscle axis) has recently been suggested to contribute to the development of sarcopenia in patients with cirrhosis (11)
Accordingly, our evidence for their formation is indirect
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The available window for an agonist to produce a measurable increase is compressed, because half the signal is already spent, so a genuine agonist effect can look smaller than it is
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