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N Engl J Med 373(22):21172128 Editor information Editors and Affiliations Glossary Glossary ADA: American Diabetes Association ANP: atrial natriuretic peptide ARB: angiotensin-receptor blocker ASCVD: atherosclerotic cardiovascular disease CANVAS: Canagliflozin Cardiovascular Assessment Study CKD: chronic kidney disease CPCs: cardiac progenitor cells CREDENCE: Canagliflozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation CV cardiovascular CVD-Real 2: Comparative Effectiveness of Cardiovascular Outcomes in New Users of Sodium- Glucose Cotransporter-2 Inhibitors CVD: cardiovascular disease DAPA-HF: Dapagliflozin and Prevention of AdverseOutcomes in Heart Failure DECLARE-TIMI 58: Dapagliflozin Effect on Cardiovascular Events DPP4-i: dipeptidyl peptidase-4 inhibitors EASD: European association for the study of Diabetes EASEL: Evidence for Cardiovascular Outcomes With Sodium Glucose Cotransporter 2 Inhibitors in the Real World ELIXA: Evaluation of Lixisenatide in Acute Coronary Syndrome EMPAREG: The Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus PatientsRemoving Excess Glucose ESRD: end-stage renal disease EXSCEL: Exenatide Study of Cardiovascular Event Lowering Trial FDA: Food and Drug Administration FFA: free fatty acid GLP-1RA: GLP-1 receptor agonists HARMONY: Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease LEADER: Liraglutide Effect and Action in Diabetes Evaluation of Cardiovascular Outcome Results MACE: Major Cardiovascular Events NAFLD: non-alcoholic hepatic steatosis NYHA: New York Heart Association PIONEER 6: Peptide Innovation for Early Diabetes Treatment REWIND: Researching Cardiovascular Events with a Weekly Incretin in Diabetes SGLT2i: Sodium/glucose-2 cotransporter inhibitors STEMI: ST-segment elevation myocardial infarction SUSTAIN: Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes 6 (SUSTAIN-6) T2D: type 2 diabetes UKPDS: United Kingdom Prospective Diabetes Study VADT: Veterans Affairs Diabetes Trial Rights and permissions Copyright information 2020 Springer Nature Switzerland AG About this chapter Cite this chapter Bertoccini, L., Baroni, M.G

Using a federated biomedical platform integrating 23 million de-identified U.S