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Collectively, these actions address several of the metabolic consequences that estrogen withdrawal sets in motion, including worsening insulin resistance, dyslipidemia, and chronic low-grade inflammation

Patients often begin to experience reduced appetite and initial weight loss during this phase

Retatrutide at 8mg showed hunger reductions of 11.4 points versus placebo at week 12

While the marketing authorisation covers adults with a BMI of 30 kg/m or greater, or 27 kg/m or greater with at least one weight-related comorbidity, NHS funding via NICE (TA664) has more specific criteria

Brief exposure (under an hour at room temperature) is generally fine

Hers uses a similar online questionnaire, but some states require a live video or audio appointment rather than an async review