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Novel Therapeutic Innovation The introduction and commercial success of GLP-1 receptor agonists - both injectable and oral - have demonstrated that next-generation therapies can meaningfully change disease management paradigms

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Furthermore, a recent clinical study in women with obesity treated with semaglutide showed improved recognition of basic tastes, altered gene expression in the tongue (measured by tongue biopsy), decreased activation of putamen in response to calorie-dense sweet and savory food cues, and increased cortical brain activity in response to the sweet taste stimulus compared to placebo