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Basic science experiments demonstrated weight-independent immunomodulatory effects of GLP-1 analogs through inhibition of the NF-B pathway (via AMP-activated protein kinase phosphorylation in psoriasis and prevention of IB phosphorylation in rheumatoid arthritis), the researchers wrote

One example is the oxidative burst of neutrophils, which is a necessary part of normal immune function

While these findings have not been linked to serious adverse outcomes so far, they highlight the need for long-term safety studies, which are currently underway in Phase 3 trials

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To normalize read counts, RPKM (Reads Per Kilobase of transcript per Million mapped reads) values were calculated in 100-bp bins using bamCoverage from deepTools (v3.5.1)

What are the key differences between Orforglipron and Semaglutide