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Diabetes, hypertension, and cardiovascular disease
The boxed warning specifically contraindicates tirzepatide use in patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
The side effects typically subside over time as the patient gets used to taking the medication and their body adjusts to the dosage
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However, at supraphysiological doses, its partial COX inhibition may contribute to mild gastrointestinal or hypertensive effects, emphasizing the need for balanced dosing and further clinical evaluation (Mohan et al., 2021)
