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While many compounds can force the growth of new blood vessels (angiogenesis), they often do so in a disorganized way that can lead to leaky vessels or unwanted tissue growth

But, there is not enough understanding about the complete effect of extended and repeated use for many years

The notion of a sleep factor has never really been accepted

Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig

The Journal of Clinical Investigation, 92 (5), 2368-2376.

This integrated perspective not only refines our mechanistic understanding but also unveils innovative avenues for effective intervention in PD