Regulatory T cell differentiation is controlled by aKG- induced alterations in mitochondrial metabolism and lipid homeostasis
Isolated MM cells were cultured in Iscoves modified Dulbecos medium supplemented with 20% FBS, insulin, selenium, transferrin, 10 g/ml of gentamycin, 10 ng/ml of interleukin-6, insulin-like growth factor-1 and vascular endothelial growth factor
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However, these mice do not display the TDP-43 pathology that is present in almost all cases of ALS, and therefore they have been increasingly criticized as a disease model