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Subsequent studies demonstrated that apelin signaling is highly context dependent, with differential coupling to G_i, G_q, and -arrestin pathways depending on ligand structure, receptor density, and tissue environment (Murali and Aradhyam, 2023)
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Biochimica Biophysica Acta (BBA) - Bioenergetics 1797, 11301137
Studies are planned to further evaluate NPI-001 and NPI-002 as potential treatments for AMD and Stargardt disease
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Therefore, basolateral LPL access to chylomicrons may be required
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