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J Cell Biol 161(6):11631177 Fantin A et al (2013) NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis

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It's particularly effective when combined with other brightening ingredients like vitamin C and niacinamide, as found in this mask

Populations of particular concern based on mechanism and the absence of human data include: individuals with active or suspected malignancy (pro-angiogenic preclinical profile)