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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus (under the brand name Ozempic) and chronic weight management (as Wegovy)

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By applying transcriptome sequencing to determine the possible pharmaceutical target of N-methyl-N-nitrosourea (MNU)-induced mouse models, researchers ascertained that ubiquitination and degradation of GPX4, catalyzed by Cullin-7, resulted in PR ferroptosis (112)