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FIGURE 9 Summary and conclusions: Glutathione and early (premature) inflammaging Chronic inflammatory diseases especially those compromising the lower respiratory system (chronic obstructive pulmonary disease, lower respiratory infections, cystic fibrosis, idiopathic pulmonary fibrosis, acute respiratory distress syndrome), diseases compromising the cardiovascular system (atherosclerosis, ischemic heart disease, stroke, and others), many other systemic inflammatory diseases like diabetes (274, 275)

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Nothing about the dose size changes across phases in the documented protocol only the frequency changes

In addition, there is evidence that creatine contributes to osmoregulation in fish for adaptations to changes in the salinities of the ambient water

Weak Immune System : Increased susceptibility to illness or infections