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It upregulates key pro-adipogenic transcription factors such as sterol regulatory element-binding protein-1c (SREBP1c), which is a major regulator that initiates the de novo synthesis of fatty acids in the liver, and enhances the activity of lipogenic enzymes, including fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD1), and lipoprotein lipase (LPL), leading to increased lipid accumulation and adipogenesis [54]
Signalling from the periphery to the brain that regulates energy homeostasis
The underlying pharmacological mechanism remains unclear [67]
If cost is the primary barrier, I often recommend maximizing the dose of low-cost generic metformin and adding a sulfonylurea like glimepiride or glipizide, while closely monitoring for hypoglycemia. Regardless, an alternative to Synjardy is only viable if a healthcare professional thinks its a good fit for you
Treatment duration varies based on individual goals
The conditions that tirzepatide was designed to treat, type 2 diabetes and obesity, share root causes with the conditions it may incidentally help, including migraines
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