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None, except the FDA indication

A ten-week treadmill training program in APP/PS1 mice also restored hippocampal memory and dendritic arbor in the CA1 and CA3 regions via BDNF/TrkB signaling pathways [389]

doi:10.1016/j.jaad.2015.07.017 30Botelho LF, Picosse FR, Padilha MH, Michalany N, Gis A, Porro AM

We observed significant changes in physiological, & neurobehavioral parameters in OVX, CUMS, and OVX + CUMS group rats

This process not only enhances loading capacity but also improves retention, as the encapsulated molecules remain ion-trapped inside the vesicle

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