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Still, there are limitations: higher dropout rates due to adverse effects in the semaglutide group, possible unblinding due to gastrointestinal side effects and weight loss, and the cerebrospinal fluid (CSF) sub-study was much smaller than the main trial. What are the real-world implications

Results from the TRIUMPH-1 trial, presented at the American Diabetes Association Scientific Sessions, show potential for retatrutide, an investigational GIP, GLP-1, and glucagon triple hormone receptor agonist, for treating obesity

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Exploratory models assess doseresponse relationships, tolerability, and sustainability of weightrelated outcomes over multiweek to multimonth protocols

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