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Animal studies using the gold-standard euglycemic clamp technique confirmed that even chronic AOD-9604 treatment produced no adverse effects on insulin sensitivity, despite significant fat loss occurring

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Tips: Aim to get sunlight exposure (outside) early in the morning (sunrise if possible) and evening sun (sunset if possible) as often as you can

These include: Increased appetite and food cravings , which may work against Wegovy's appetite-suppressing effects Insulin resistance and elevated blood glucose levels , potentially leading to steroid-induced diabetes Fluid retention and weight gain , particularly in the face, neck, and trunk (cushingoid features) Redistribution of body fat to central areas Muscle wasting , which can reduce metabolic rate Patients taking both medications may experience reduced weight loss efficacy compared to those taking Wegovy alone, though the appetite-suppressing effects of Wegovy may help mitigate steroid-induced hunger

The answer here is yes, but the side effects are no more prevalent when combining the medications than when taking one or the other, and they don't necessarily make each other worse

Nat Rev Dis Primers (2016) 2:16065