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Arch Intern Med Res

Variability Across Study Designs Safety signals in published studies vary due to differences in: species used (rodents vs other models) dosing magnitude route of administration model type (injury-induced vs healthy tissue) study duration This variability limits the ability to draw broad conclusions

This makes sense on paper, but there are no large human studies proving the combo works better than using just one

it required deliberate medicinal chemistry to shift binding affinity by 50-fold

The global sensitivity analysis suggests that the comproportionation reaction, R 5 , is not pivotal for the model OCR output, given that its parameters, k p5 and k m5 , are the two least sensitive parameters for both main and total interactions