Underlying causes unaddressed
The vitamin continues to support healthy nerve function over this period
Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations GSH: reduced glutathione GSSG: glutathione disulfide GS: thyil radical ROS: reactive oxygen species RNS: reactive nitrogen species RS: reactive species -GCS: -glutamylcysteine synthetase GPX: glutathione peroxidase GR: glutathione reductase GST: glutathione S -transferase GSNO: nitrosoglutathione G6PD: glucose-6-phosphate dehydrogenase NAC: N -acetyl-L-cysteine NO: nitric oxide protein-SSG: protein glutathionylation protein-SNO: protein nitrosylation References Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L et al
Pharmacokinetics, distribution, metabolism, and excretion of body-protective compound 157 in rats and dogs

Rare: may affect up to 1 in 1,000 people Acniform and bullous eruptions (acne-like and blistery skin eruptions) Not known: frequency cannot be estimated from the available data Headache, dizziness Nausea (feeling sick), vomiting, diarrhoea Malaise (feeling unwell) Rash, itching Injection site reactions including injection site pain, injection site erythema, injection site pruritus, injection site induration, and injection site swelling (Reactions at the site of the injection) Exanthema (a widespread skin rash) Chromaturia (unusual coloured urine) Fever Hot flushes (a feeling of intense heat with sweating and rapid heartbeat) Chills (feeling of coldness accompanied by shivering) Paraesthesia (feeling of pins and needles) Tremor (tremble or shakes) Hypokalaemia (decreased potassium levels in the blood) Reactive thrombocytosis (body produces too many platelets) Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse

Sit in a comfortable, upright position and place the mouthpiece between your teeth, or wear the face mask over your nose and mouth