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Interestingly, the SUSTAIN program showed for the first time that GLP-1RA might induce an acute drop in the eGFR slope resembling the pattern observed in established nephroprotective drugs such as SGLT-2i, angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) [17]

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Late 2026 to Q1 2027: NDA submission to the FDA, assuming all trials are successful

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This comparison matters because many people consider Pendulum specifically as an alternative to medications like semaglutide and tirzepatide