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141 Management of multiple liver etiologies of MASLD is therefore an important aspect of avoiding adverse clinical outcomes
Findings included: Average body weight reduction: 18.3% Average leg volume reduction (perometry): 11.4% Pain reduction (VAS score): improved from 6.2/10 to 3.1/10 on average 12 of 18 patients (67%) reported subjective softening of previously firm, nodular tissue While case series aren't definitive evidence, the leg volume reduction of 11.4% is notable because lipedema fat typically shows minimal response to weight loss interventions
This opens the door to complementing existing treatments for alcohol use disorder with a GLP-1 receptor-targeted approach, he adds
In the SURMOUNT-1 trial (N=2,539), tirzepatide 15 mg produced 22.5% mean body weight loss at 72 weeks versus 2.4% with placebo [16]
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