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Airway epithelial-specific knockout of LONP1 in mice results in the loss of differentiation capacity of primitive airway progenitor cells into club cells and ciliated cells, instead driving their differentiation into dysfunctional luminal cells

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In the case of L-carnitine, the evidence is mixed : some trials and reviews find modest changes in certain indicators, while others show no relevant differences

GDMT for HFrEF typically includes evidence-based beta-blockers, angiotensin receptor neprilysin inhibitors (ARNIs), angiotensin receptor blockers (ARBs), angiotensin-converting enzyme (ACE) inhibitors, mineralocorticoid receptor antagonists (MRA), and sodium-glucose cotransporter 2 inhibitors (SGLT2is), particularly in patients with obesity or T2DM [53]

(PubMed) Nesby-O'Dell S, Scanlon KS, Cogswell ME, et al