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Glutamatergic and GABAergic inputs set the tempo in GHRH neurons upon sustained somatostatin stimulation The spontaneous firing activity of GHRH neurons is mainly driven by a local (hypothalamic) balance between glutamatergic (excitatory) and GABAergic (inhibitory) neuronal inputs 8,9
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However, a posterior analysis done specifically in those methylcobalamin-treated patients who were diagnosed and started the study earlier (a year or less after symptom onset) showed that methylcobalamin exhibited efficacy, or a trend towards efficacy
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Reconstitution & handling The lyophilized 5 mg powder should be stored cold and protected from light and moisture until preparation
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