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After 5 days at 0.25mg with no adverse effects, the protocol advances to 0.5mg daily for another 57 days

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11,12 Second, shifts in the population-level distribution of risk factors have also played an important role

Starting with a lower dose and gradually adjusting can help manage these effects, and they usually go away on their own as your body adjusts

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Comparative Efficacy: Weight Loss Outcomes (SURMOUNT vs STEP) There are no published head-to-head clinical trials comparing semaglutide and tirzepatide directly