It is studied in preclinical models to investigate selective lipolysis stimulation, adipocyte metabolism regulation, body composition effects, and metabolic parameter modulation
SIRT1 targets both histone and non-histone substrates, including histones (e.g., H3K9, H4K16 31 ) and transcriptional regulators such as p53, 32 FOXO1/3a, 33 PGC-1, 34 LKB1, 35 and NF-B p65, 36 thereby contributing to epigenetic regulation and broader cellular functions
Trong cc trng hp khc, nh h tr iu tr chng suy gim t duy lin quan n tui tc, s dng trong thi gian di hn, thm ch ln n 6 thng, c th l cn thit nh gi hiu qu y
Primary research areas include gastrointestinal tract studies (gastric ulcer, inflammatory bowel models, esophagitis, fistula healing), musculoskeletal tissue studies (Achilles tendon transection, ligament healing, muscle crush injury), and neuroprotective models (dopaminergic system interactions, peripheral nerve transection)
Cell ageing is largely caused by oxidative stress
