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The 545 amino acid isoform a protein is inactive but post-translational processing results in a 515 amino acid functional protein containing an acetylated alanine residue at the N-terminus
Targeted delivery to peripheral nerves remains challenging due to the blood-nerve barrier, and off-target effects can pose safety risks
Mechanism of Action: It works by promoting angiogenesis (the formation of new blood vessels), reducing inflammation, and enhancing tissue repair (Zhao et al., 2020)
One study conducted on swine with ischemic cardiomyopathy found that GHRH analog reduced the size of infarct and improved diastolic strain
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