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R., Hartoft-Nielsen, M., et al
While these are population-level numbers, the principle applies to individuals as well: routine injection visits for non-deficient patients add up in copays, travel time, and appointment scheduling without delivering additional benefit
Standard mitigation strategies include eating smaller, lower-fat meals and slowing the dose escalation schedule if symptoms are severe
Elevated cortisol from chronic stress and sleep deprivation both increase hunger signals and promote fat storage, working directly against what the medication is trying to do
By enhancing satiety and reducing hunger, tirzepatide makes it easier for patients to stick to a healthy eating plan and achieve long-term weight loss goals
Science 331 , 304308 (2011)
