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This phospholipid can be synthesized from dietary choline via the cytidine diphosphocholine (CDP-choline) pathway or through the methylation of another phospholipid, phosphatidylethanolamine ( Figure 2 ) (3)

M.Pavarino-BertelliE

Mitochondria constantly undergo fusion (joining) and fission (splitting) to adapt to changing energy demands

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Similarly, deleting AMPK1 gene altered the differentiation pathway of M-MDSCs, leading them to adopt a cytotoxic role against tumors through nitric oxide synthase 2, highlighting the central role of AMPK1 in MDSC-mediated immunosuppression