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[1] Orforglipron: A Milestone in Oral GLP-1 RA Development Eli Lilly also presented positive topline Phase 3 results from ACHIEVE-1, evaluating the safety and efficacy of orforglipron compared to placebo in adults with type 2 diabetes and inadequate glycemic control with diet and exercise alone

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2026 Jan;69(1):3649

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However, more serious reactions have been reported, like pancreatitis, kidney problems, and an increased risk of diabetic retinopathy complications in those with a history of diabetic eye disease