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A randomized controlled trial on the effect of metformin in CHD patients without diabetes showed that it (2000 mg/day, P.O for 12 months) not only decreased oxidative stress but also lowered left ventricular mass (LVM) and improved blood pressure [227]

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Heres a breakdown to help you decide: Use IGF-1 LR3 If You Want: Direct muscle growth , especially during bulking or recomposition Faster recovery between intense workouts or injuries A shorter cycle with measurable hypertrophy and enhanced nutrient uptake Use HGH If You Want: Body fat reduction , especially around the midsection Support for joints, skin, and recovery during calorie deficits or aging A slow and steady body composition shift over longer time frames The anabolic effects of GH are mediated through IGF-1, but IGF-1 LR3 offers direct action and superior local hypertrophy when used independently. Velloso, C.P., Growth Hormone & IGF Research Stacking Consideration : For experienced users seeking maximum muscle growth, fat loss, and joint support , a carefully timed HGH + IGF-1 LR3 protocol may provide synergistic effects , especially when paired with testosterone or other anabolic agents

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