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167,171,172 Management strategies focus on tight glycemic control to prevent further nerve damage, symptomatic treatment with analgesics for pain management, physical therapy to maintain muscle strength and prevent contractures, and surgical interventions for entrapment neuropathies when necessary

[16] [17] However, in othersespecially those who lose weight very rapidlymenstrual cycles may become irregular or cease altogether

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People interested in investigational access should look for properly registered trials rather than informal sources

If diarrhea is severe, reduce the dose by half until symptoms improve

However, the two agencies do collaborate, and Health Canada often expedites review for medications already approved by the FDA