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For this reason, researchers should design protocols with realistic endpoints focused on liver function, metabolic biomarkers, and nutrient status rather than dramatic body composition changes

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Long-term use requires monitoring for side effects such as oral thrush, hoarseness, and the potential impact on bone density

CagriSema produced unprecedented mean weight loss of 20.4% at 68 weeks on an intent-to-treat basis, significantly exceeding semaglutide alone (14.9%), cagrilintide alone (11.5%), and placebo (3.0%)