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If iron deficient, the erythrocytes are no longer released and when they are retained in the marrow, they continue to divide

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However, if the interruption exceeded two weeks , many clinicians recommend restarting at a lower dose (usually 0.25 mg weekly) and gradually re-titrating upwards according to the licensed schedule (0.25 mg 0.5 mg 1 mg, and potentially to 2 mg for type 2 diabetes) over 48 weeks to reduce gastrointestinal side effects

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