The reduction in inflammatory markers such as hs-CRP and IL-6 may contribute to improved endothelial function, reduced atherosclerotic progression, and better overall cardiometabolic health
Researchers started every participant at the same base dose regardless of their target maintenance level, then increased the dose every four weeks until reaching the assigned tier
A meta-analysis of seven studies including 1,757 participants with type 2 diabetes found that SGLT2 inhibitor therapy in combination with blood pressure medications (known as renin-angiotensin system blockers) was well-tolerated and resulted in greater improvement in blood pressure, glucose control, body weight, and indices of kidney function compared with the blood pressure drugs alone (Tian 2021)
However, although the mean baseline A1C over time has decreased for people with T2D, at the end of the study period, the A1C value was still over 6.5% (the percent at which diabetes is diagnosed) (Centers for Disease Control and Prevention, 2022)
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